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Aging itself leads to many health implications (Jaul et al

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A meta-analysis of randomized controlled trials found that daily vitamin E supplementation equivalent to 25 to 536 mg/day of RRR --tocopherol for several years resulted in a significant, 10% reduction in the risk of ischemic stroke (five trials, 91,393 participants) and a nonsignificant trend towards an increased risk of hemorrhagic stroke (five trials, 100,748 participants) (120)

This route supports the predictable use of peptide drugs for endocrine disorders, immune modulation, tissue repair, and neurologically targeted interventions

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